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Bam 15 API Intermediate

Name: Bam 15 API Intermediate
Brand: NIMAI CORP PRIVATE LIMITED
Price: 10000.0 INR
Availability: InStock

Price 10000.0 INR/ Kilograms

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MOQ : 1 Kilograms

Bam 15 API Intermediate Specification

Molecular Weight
180 Grams (g)

Shelf Life
2 Years

Storage
Freezer

Medicine Name
Bam 15

Chemical Name
2-fluorophenyl {6-(2-fluorophenyl)amino}amine)

CAS No
210302-17-3

Type
Pharmaceutical Intermediates

Grade
Medicine Grade

Usage
BAM-15 (scientific name: 2-fluorophenyl {6-(2-fluorophenyl)amino}amine) is a chemically synthesized compound that functions as a mitochondrial uncoupler. To understand its action, one must first understand the process of oxidative phosphorylation. In normal cellular respiration, the electron transport chain (ETC) pumps protons across the mitochondrial inner membrane, creating a proton gradient. This gradient drives the enzyme ATP synthase to produce adenosine triphosphate (ATP), the cell's primary energy currency. Mitochondrial uncouplers, like BAM-15, disrupt this process by shuttling protons back across the membrane, bypassing ATP synthase. This "short-circuit" dissipates the proton gradient as heat, thereby reducing the efficiency of ATP production. Consequently, the cell must increase its metabolic rate and oxidize more substrates (including fats and glucose) to meet its energy demands. Unlike earlier uncouplers such as 2,4-dinitrophenol (DNP), which was effective but notoriously toxic, BAM-15 has been specifically engineered for a superior safety profile, demonstrating high selectivity for the mitochondrial membrane without disrupting its integrity.

Purity(%)
99%

Physical Form
Powder

Bam 15 API Intermediate Trade Information

Minimum Order Quantity
1 Kilograms

Payment Terms
Cash in Advance (CID)

Supply Ability
5000 Kilograms Per Month

Delivery Time
10 Days

Sample Policy
Free samples are available

Main Domestic Market
All India

About Bam 15 API Intermediate

1.Weight Management and Anti-Obesity Effects: BAM-15 potently increases energy expenditure. By forcing the body to burn more fuel to produce the same amount of ATP, it creates a significant negative energy balance. Research has shown that treatment with BAM-15 leads to reduced fat mass and body weight in diet-induced obese mice, without the need for calorie restriction. This positions it as a powerful potential agent for pharmacological weight management.

2.Improvement of Insulin Sensitivity and Glycemic Control: BAM-15 enhances glucose homeostasis. By promoting the oxidation of excess nutrients and reducing lipid accumulation in non-adipose tissues like the liver and skeletal muscle-a phenomenon known as lipotoxicity-it improves insulin signaling. Studies indicate that BAM-15 treatment lowers fasting blood glucose and insulin levels, effectively reversing insulin resistance, a cornerstone of type 2 diabetes.

3.Amelioration of Non-Alcoholic Fatty Liver Disease (NAFLD): The liver is a primary site of lipid metabolism. BAM-15 has demonstrated a profound ability to reduce hepatic steatosis (fatty liver) by increasing fatty acid oxidation within hepatocytes. Furthermore, by reducing oxidative stress and inflammation-common sequelae of a fatty liver-it shows potential to halt or even reverse the progression of NAFLD to its more severe form, non-alcoholic steatohepatitis (NASH).

4.Anti-inflammatory and Anti-aging Potential: Emerging evidence suggests that mild mitochondrial uncoupling can reduce the production of reactive oxygen species (ROS), a key driver of cellular aging and inflammation. BAM-15 has been shown to lower inflammatory markers, suggesting benefits that may extend beyond pure metabolism to age-related and inflammatory conditions.

High-Purity Medicine-Grade Intermediate

Bam 15 API Intermediate is manufactured with exceptional purity (99%), ensuring reliable performance in pharmaceutical synthesis. Its outstanding quality enables pharmaceutical companies and laboratories to confidently use it for advanced research and drug development. This intermediate supports strict industry standards and consistent results.

Essential Role in Mitochondrial Research

As a mitochondrial uncoupler, Bam 15 actively participates in disrupting the proton gradient during cellular respiration. This unique action aids scientists in exploring metabolic processes and potentially developing novel therapies for metabolic disorders, cancer, and obesity. Its precise mechanism of action makes it an invaluable tool for biochemical studies.

Safe Handling and Storage Recommendations

To preserve its stability and prevent degradation, Bam 15 should be stored in a freezer. By following recommended storage protocols and ensuring proper handling, its 2-year shelf life can be fully utilized, maintaining the integrity required for medicine-grade applications and reliable experimental results.

FAQ's of Bam 15 API Intermediate:

Q: How should Bam 15 API Intermediate be stored to maintain its stability?

A: Bam 15 API Intermediate should be stored in a freezer to ensure its chemical stability and to preserve its 2-year shelf life. Cold storage prevents degradation and maintains its high purity for pharmaceutical use.

Q: What is the primary usage of Bam 15 API Intermediate in the pharmaceutical industry?

A: Bam 15 is mainly used as an intermediate during the synthesis of medicine. It is particularly valued for its function as a mitochondrial uncoupler, facilitating research and development of drugs targeting metabolic pathways.

Q: When is Bam 15 API Intermediate typically incorporated into pharmaceutical research?

A: Bam 15 is incorporated during advanced stages of pharmaceutical research when studying mitochondrial function or developing medications that modulate cellular metabolism. Its unique properties make it suitable for both exploratory research and experimental drug synthesis.

Q: Where can Bam 15 API Intermediate be sourced or purchased?

A: Bam 15 API Intermediate is available from certified exporters, manufacturers, suppliers, and traders based in India. Its pharmaceutical-grade quality ensures it meets industry standards for research and production.

Q: What process does Bam 15 influence at the cellular level?

A: Bam 15 acts as a mitochondrial uncoupler. It disrupts the proton gradient created during oxidative phosphorylation, affecting ATP synthesis, which helps scientists study mitochondrial function and energy metabolism.

Q: How does using Bam 15 API Intermediate benefit pharmaceutical development?

A: Utilizing Bam 15 enables researchers to better understand mitochondrial mechanisms, supporting the development of innovative therapies for diseases like obesity and metabolic disorders. Its stability and high purity contribute to the accuracy of experimental results.

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